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Target
Receptor-interacting serine/threonine-protein kinase 2
Ligand
BDBM50279290
Substrate
n/a
Meas. Tech.
ChEMBL_1720584 (CHEMBL4135584)
IC50
21±n/a nM
Citation
 He, X; Da Ros, S; Nelson, J; Zhu, X; Jiang, T; Okram, B; Jiang, S; Michellys, PY; Iskandar, M; Espinola, S; Jia, Y; Bursulaya, B; Kreusch, A; Gao, MY; Spraggon, G; Baaten, J; Clemmer, L; Meeusen, S; Huang, D; Hill, R; Nguyen-Tran, V; Fathman, J; Liu, B; Tuntland, T; Gordon, P; Hollenbeck, T; Ng, K; Shi, J; Bordone, L; Liu, H Identification of Potent and Selective RIPK2 Inhibitors for the Treatment of Inflammatory Diseases. ACS Med Chem Lett 8:1048-1053 (2017) [PubMed]  Article 
Target
Name:
Receptor-interacting serine/threonine-protein kinase 2
Synonyms:
CARDIAK | RICK | RIP2 | RIPK2 | RIPK2_HUMAN | Serine/threonine-protein kinase RIPK2 | Tyrosine-protein kinase RIPK2 | receptor-interacting serine/threonine-protein kinase 2
Type:
Protein
Mol. Mass.:
61201.30
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
540
Sequence:
MNGEAICSALPTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRILHEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAPEGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSVSQGHRPVINEESLPYDIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFEEITFLEAVIQLKKTKLQSVSSAIHLCDKKKMELSLNIPVNHGPQEESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVSRSPSLNLLQNKSM
  
Inhibitor
Name:
BDBM50279290
Synonyms:
CHEMBL4171039
Type:
Small organic molecule
Emp. Form.:
C20H23N3O4S
Mol. Mass.:
401.479
SMILES:
COc1cc2ncc(-c3cccc(NC(C)=O)c3)n2cc1S(=O)(=O)C(C)(C)C
Structure:
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