Reaction Details Report a problem with these data
Target
Neuromedin-U receptor 1
Ligand
BDBM50336023
Substrate
n/a
Meas. Tech.
ChEMBL_1734437 (CHEMBL4149973)
IC50
8.8±n/a nM
Citation
 De Prins, A; Martin, C; Van Wanseele, Y; Tömböly, C; Tourwé, D; Caveliers, V; Holst, B; Van Eeckhaut, A; Rosenkilde, MM; Smolders, I; Ballet, S Synthesis and  ACS Med Chem Lett 9:496-501 (2018) [PubMed]  Article 
Target
Name:
Neuromedin-U receptor 1
Synonyms:
G-protein coupled receptor 66 | G-protein coupled receptor FM-3 | GPR66 | NMU-R1 | NMUR1 | NMUR1_HUMAN | Neuromedin-U receptor 1
Type:
PROTEIN
Mol. Mass.:
47370.42
Organism:
Human
Description:
ChEMBL_103121
Residue:
426
Sequence:
MTPLCLNCSVLPGDLYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELFMPICATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYEMWHNYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIRQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLFVLVVVFGICWAPFHADRVMWSVVSQWTDGLHLAFQHVHVISGIFFYLGSAANPVLYSLMSSRFRETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGPEAQQETDPS
  
Inhibitor
Name:
BDBM50336023
Synonyms:
CHEMBL4162351
Type:
Small organic molecule
Emp. Form.:
C58H82N16O11
Mol. Mass.:
1179.3723
SMILES:
CC(C)C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(C)=O)C(=O)NC1(CCc2ccccc2C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(N)=O |r|
Structure:
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