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Target
Platelet-activating factor receptor
Ligand
BDBM50018384
Substrate
n/a
Meas. Tech.
ChEMBL_154996 (CHEMBL767100)
IC50
30±n/a nM
Citation
 Guthrie, RW; Kaplan, GL; Mennona, FA; Tilley, JW; Kierstead, RW; Mullin, JG; LeMahieu, RA; Zawoiski, S; O'Donnell, M; Crowley, H Pentadienyl carboxamide derivatives as antagonists of platelet-activating factor. J Med Chem 32:1820-35 (1989) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF Platelet activating factor | PAF-R | PAFR | PTAFR | PTAFR_HUMAN | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39219.60
Organism:
Homo sapiens (Human)
Description:
PAF Platelet activating factor PTAFR HUMAN::P25105
Residue:
342
Sequence:
MEPHDSSHMDSEFRYTLFPIVYSIIFVLGVIANGYVLWVFARLYPCKKFNEIKIFMVNLTMADMLFLITLPLWIVYYQNQGNWILPKFLCNVAGCLFFINTYCSVAFLGVITYNRFQAVTRPIKTAQANTRKRGISLSLVIWVAIVGAASYFLILDSTNTVPDSAGSGNVTRCFEHYEKGSVPVLIIHIFIVFSFFLVFLIILFCNLVIIRTLLMQPVQQQRNAEVKRRALWMVCTVLAVFIICFVPHHVVQLPWTLAELGFQDSKFHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLTEKFYSMRSSRKCSRATTDTVTEVVVPFNQIPGNSLKN
  
Inhibitor
Name:
BDBM50018384
Synonyms:
5-(4-Methoxy-phenyl)-hepta-2,4-dienoic acid (1-methyl-4-pyridin-3-yl-butyl)-amide | CHEMBL299856
Type:
Small organic molecule
Emp. Form.:
C24H30N2O2
Mol. Mass.:
378.5072
SMILES:
CC\C(=C/C=C/C(=O)N[C@H](C)CCCc1cccnc1)c1ccc(OC)cc1
Structure:
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