Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit gamma-1
Ligand
BDBM50018800
Substrate
n/a
Meas. Tech.
ChEMBL_68607 (CHEMBL681141)
IC50
25±n/a nM
Citation
 Palmer, CJ; Cole, LM; Carida, JE (+/-)-4-tert-butyl-3-cyano-1-(4-ethynylphenyl)-2,6,7-trioxabi cyclo[2.2.2]octane: synthesis of a remarkably potent GABAA receptor antagonist. J Med Chem 31:1064-6 (1988) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit gamma-1
Synonyms:
Benzodiazepine receptors | Benzodiazepine receptors; peripheral & central | GABA receptor gamma-1 subunit | GBRG1_RAT | Gabrg1
Type:
PROTEIN
Mol. Mass.:
53557.84
Organism:
Rattus norvegicus
Description:
ChEMBL_193817
Residue:
465
Sequence:
MGSGKVFLFSPSLLWSQTRGVRLIFLLLTLHLGNCIDKADDEDDEDLTMNKTWVLAPKIHEGDITQILNSLLQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDIIFAQTWFDSRLKFNSTMKVLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWSDGRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYWRLYQFAFVGLRNSTEISHTISGDYIIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSFWINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYGTLHYFTSNNKGKTTRDRKLKSKTSVSPGLHAGSTLIPMNNISMPQGEDDYGYQCLEGKDCATFFCCFEDCRTGSWREGRIHIRIAKIDSYSRIFFPTAFALFNLVYWVGYLYL
  
Inhibitor
Name:
BDBM50018800
Synonyms:
4-tert-Butyl-1-(4-ethynyl-phenyl)-2,6,7-trioxa-bicyclo[2.2.2]octane-3-carbonitrile | CHEMBL10450
Type:
Small organic molecule
Emp. Form.:
C18H19NO3
Mol. Mass.:
297.3484
SMILES:
n/a
Structure:
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