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Target
Mitogen-activated protein kinase
Ligand
BDBM50151363
Substrate
n/a
Meas. Tech.
ChEMBL_1743519 (CHEMBL4178029)
IC50
>10000±n/a nM
Citation
 Osman, KT; Ye, J; Shi, Z; Toker, C; Lovato, D; Jumani, RS; Zuercher, W; Huston, CD; Edwards, AM; Lautens, M; Santhakumar, V; Hui, R Discovery and structure activity relationship of the first potent cryptosporidium FIKK kinase inhibitor. Bioorg Med Chem 25:1672-1680 (2017) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase
Synonyms:
2.7.11.24 | Mitogen-activated protein kinase
Type:
PROTEIN
Mol. Mass.:
80142.44
Organism:
Cryptosporidium parvum (strain Iowa II)
Description:
ChEMBL_117877
Residue:
710
Sequence:
MCDRVDRHVLRKYELVKKLGKGAYGIVWKSIDRRTGEVVAVKKIFDAFQNSTDAQRTFREIMILTELSGHENIVNLLNVLRADNDRDVYLVFDYMETDLHAVIRANILEPVHKQYVVYQLIKVIKYLHSGGLLHRDMKPSNILLNAECHVKVADFGLSRSFVNIRRVTNNIPLSINENTENFDDDQPILTDYVATRWYRAPEILLGSTKYTKGIDMWSLGCILGEILCGKPIFPGSSTMNQLERIIGVIDFPSNEDVESIQSPFAKTMIESLKEKVEIRQSNKRDIFTKWKNLLLKINPKADCNEEALDLLDKLLQFNPNKRISANDALKHPFVSIFHNPNEEPNCDHIITIPINDNVKHSIDDYRNLVYSEISRRKRELISNKHQNVQNPNTAVSNPRVNRVSGAVEFATPECNPDNITSNKSNEPIYSKFQSELQSNKRSSINKNPPADNSKKGGILGNFFSQVYNTFISGSATNKTTSFGNSPAISNFSNGKVDEKHIQQMRSAASYYSSSINNSNPIKKGGGFIGNNLSSTNDNTTKATNSSTKNSKYISTGAVIKNANSTFSVSTNCGGNSHVYYPRAYMYNNIKHNLPDYSLIPNSESSNSLLGKNTSNLKYSNNPELSNQFKLNCHGSNQTSIINLQMQQNRSNTSKITYYNEPNIEPNSKLNDMVGRKSTSSGVGVNTLHHPPPFYTSQQNKNVNKNYLYKY
  
Inhibitor
Name:
BDBM50151363
Synonyms:
4-(3-Chloro-phenyl)-5-[1,5]naphthyridin-2-yl-thiazol-2-ylamine | 4-(3-chlorophenyl)-5-(1,5-naphthyridin-2-yl)thiazol-2-amine | CHEMBL365663
Type:
Small organic molecule
Emp. Form.:
C17H11ClN4S
Mol. Mass.:
338.814
SMILES:
Nc1nc(c(s1)-c1ccc2ncccc2n1)-c1cccc(Cl)c1
Structure:
Search PDB for entries with ligand similarity: