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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50192831
Substrate
n/a
Meas. Tech.
ChEMBL_1747074 (CHEMBL4181584)
EC50
>10000±n/a nM
Citation
 Lagu, B; Kluge, AF; Fredenburg, RA; Tozzo, E; Senaiar, RS; Jaleel, M; Panigrahi, SK; Tiwari, NK; Krishnamurthy, NR; Takahashi, T; Patane, MA Novel highly selective peroxisome proliferator-activated receptor ? (PPAR?) modulators with pharmacokinetic properties suitable for once-daily oral dosing. Bioorg Med Chem Lett 27:5230-5234 (2017) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50192831
Synonyms:
CHEMBL3895104 | US10188627, Compound 8h
Type:
Small organic molecule
Emp. Form.:
C26H29NO5
Mol. Mass.:
435.5122
SMILES:
CC(CCOc1ccccc1CN(C)C(=O)c1ccc(cc1)-c1ccco1)CCC(O)=O
Structure:
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