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Target
Casein kinase I isoform delta
Ligand
BDBM50455467
Substrate
n/a
Meas. Tech.
ChEMBL_1754449 (CHEMBL4189209)
IC50
270±n/a nM
Citation
 García-Reyes, B; Witt, L; Jansen, B; Karasu, E; Gehring, T; Leban, J; Henne-Bruns, D; Pichlo, C; Brunstein, E; Baumann, U; Wesseler, F; Rathmer, B; Schade, D; Peifer, C; Knippschild, U Discovery of Inhibitor of Wnt Production 2 (IWP-2) and Related Compounds As Selective ATP-Competitive Inhibitors of Casein Kinase 1 (CK1) ?/?. J Med Chem 61:4087-4102 (2018) [PubMed]  Article 
Target
Name:
Casein kinase I isoform delta
Synonyms:
CK1, delta | Casein kinase 1 Delta | Casein kinase I delta | Casein kinase I isoform delta | Csnk1d | Hckid | KC1D_RAT | casein kinase 1, delta
Type:
Enzyme
Mol. Mass.:
47342.73
Organism:
Rattus norvegicus (rat)
Description:
Q06486
Residue:
415
Sequence:
MELRVGNRYRLGRKIGSGSFGDIYLGTDIAAGEEVAIKLECVKTKHPQLHIESKIYKMMQGGVGIPTIRWCGAEGDYNVMVMELLGPSLEDLFNFCSRKFSLKTVLLLADQMISRIEYIHSKNFIHRDVKPDNFLMGLGKKGNLVYIIDFGLAKKYRDARTHQHIPYRENKNLTGTARYASINTHLGIEQSRRDDLESLGYVLMYFNLGSLPWQGLKAATKRQKYERISEKKMSTPIEVLCKGYPSEFATYLNFCRSLRFDDKPDYSYLRQLFRNLFHRQGFSYDYVFDWNMLKFGASRAADDAERERRDREERLRHSRNPATRGLPSTASGRLRGTQEVAPPTPLTPTSHTANTSPRPVSGMERERKVSMRLHRGAPVNVSSSDLTGRQDTSRMSTSQIPGRVASSGLQSVVHR
  
Inhibitor
Name:
BDBM50455467
Synonyms:
CHEMBL4212803
Type:
Small organic molecule
Emp. Form.:
C23H17F3N4O2S3
Mol. Mass.:
534.597
SMILES:
FC(F)(F)c1ccc2nc(NC(=O)CSc3nc4CCSc4c(=O)n3Cc3ccccc3)sc2c1
Structure:
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