Reaction Details Report a problem with these data
Target
Genome polyprotein
Ligand
BDBM50459250
Substrate
n/a
Meas. Tech.
ChEMBL_1765974 (CHEMBL4201221)
EC50
128±n/a nM
Citation
 Da Costa, L; Scheers, E; Coluccia, A; Casulli, A; Roche, M; Di Giorgio, C; Neyts, J; Terme, T; Cirilli, R; La Regina, G; Silvestri, R; Mirabelli, C; Vanelle, P Structure-Based Drug Design of Potent Pyrazole Derivatives against Rhinovirus Replication. J Med Chem 61:8402-8416 (2018) [PubMed]  Article 
Target
Name:
Genome polyprotein
Synonyms:
VP1 capsid protein
Type:
PROTEIN
Mol. Mass.:
32599.37
Organism:
HRV-1A
Description:
ChEMBL_116925
Residue:
287
Sequence:
NPVENYIDEVLNEVLVVPNIKESHHTTSNSAPLLDAAETGHTSNVQPEDAIETRYVITSQTRDEMSIESFLGRSGCVHISRIKVDYTDYNGQDINFTKWKITLQEMAQIRRKFELFTYVRFDSEITLVPCIAGRGDDIGHIVMQYMYVPPGAPIPSKRNDFSWQSGTNMSIFWQHGQPFPRFSLPFLSIASAYYMFYDGYDGDNTSSKYGSVVTNDMGTICSRIVTEKQKHSVVITTHIYHKAKHTKAWCPRPPRAVPYTHSHVTNYMPETGDVTTAIVRRNTITTA
  
Inhibitor
Name:
BDBM50459250
Synonyms:
CHEMBL4209270
Type:
Small organic molecule
Emp. Form.:
C17H14ClN3O3
Mol. Mass.:
343.764
SMILES:
OC(Cc1ccc(Cl)cc1[N+]([O-])=O)c1ccc(cc1)-n1cccn1
Structure:
Search PDB for entries with ligand similarity: