Reaction Details Report a problem with these data
Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50022922
Substrate
n/a
Meas. Tech.
ChEMBL_71742 (CHEMBL680264)
Kd
4.50±n/a nM
Citation
Rivier, J; Kupryszewski, G; Varga, J; Porter, J; Rivier, C; Perrin, M; Hagler, A; Struthers, S; Corrigan, A; Vale, W Design of potent cyclic gonadotropin releasing hormone antagonists. J Med Chem 31:677-82 (1988) [PubMed] Article
More Info.:
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
Inhibitor
Name:
BDBM50022922
Synonyms:
Ac-DNal-DCpa-DPal-c[Dpr-Arg-DPal-Leu-Arg-Pro-Asp]-NH2 | Ac-DNal-DCpa-DPal-c[Dpr-Arg-DPal-Leu-Arg-Pro-DAsp]-NH2 | CHEMBL442303
Type:
Small organic molecule
Emp. Form.:
C68H87ClN20O12
Mol. Mass.:
1411.998
SMILES:
CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CNC(=O)C[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)[C@H](Cc1ccc2ccccc2c1)NC(C)=O)c1cccnc1)c1cccnc1