Reaction Details Report a problem with these data
Target
Cyclin-C
Ligand
BDBM50248631
Substrate
n/a
Meas. Tech.
ChEMBL_1768107 (CHEMBL4220219)
IC50
5.0±n/a nM
Citation
 Philip, S; Kumarasiri, M; Teo, T; Yu, M; Wang, S Cyclin-Dependent Kinase 8: A New Hope in Targeted Cancer Therapy? J Med Chem 61:5073-5092 (2018) [PubMed]  Article 
Target
Name:
Cyclin-C
Synonyms:
CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11
Type:
PROTEIN
Mol. Mass.:
33244.88
Organism:
Homo sapiens (Human)
Description:
ChEMBL_107900
Residue:
283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
  
Inhibitor
Name:
BDBM50248631
Synonyms:
CHEMBL4080906
Type:
Small organic molecule
Emp. Form.:
C30H36N2O3
Mol. Mass.:
472.6184
SMILES:
[H][C@@]12CC[C@H](c3ccc4ccncc4c3)[C@@]1(C)CC=C1C=C3[C@@H](O)[C@H](O)[C@H](C[C@]33CC[C@]21O3)N(C)C |r,t:21,23|
Structure:
Search PDB for entries with ligand similarity: