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Target
Monoglyceride lipase
Ligand
BDBM50461661
Substrate
n/a
Meas. Tech.
ChEMBL_1771778 (CHEMBL4223890)
IC50
11100±n/a nM
Citation
 Lauria, S; Perrotta, C; Casati, S; Di Renzo, I; Ottria, R; Eberini, I; Palazzolo, L; Parravicini, C; Ciuffreda, P Design, synthesis, molecular modelling and in vitro cytotoxicity analysis of novel carbamate derivatives as inhibitors of Monoacylglycerol lipase. Bioorg Med Chem 26:2561-2572 (2018) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50461661
Synonyms:
CHEMBL3741979
Type:
Small organic molecule
Emp. Form.:
C20H17NO2
Mol. Mass.:
303.3545
SMILES:
O=C(Nc1cccc(c1)-c1ccccc1)OCc1ccccc1
Structure:
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