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Target
Monoglyceride lipase
Ligand
BDBM50461660
Substrate
n/a
Meas. Tech.
ChEMBL_1771781 (CHEMBL4223893)
IC50
17400±n/a nM
Citation
 Lauria, S; Perrotta, C; Casati, S; Di Renzo, I; Ottria, R; Eberini, I; Palazzolo, L; Parravicini, C; Ciuffreda, P Design, synthesis, molecular modelling and in vitro cytotoxicity analysis of novel carbamate derivatives as inhibitors of Monoacylglycerol lipase. Bioorg Med Chem 26:2561-2572 (2018) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
MAG lipase | MGLL_MOUSE | Mgll | Monoacylglycerol lipase | Monoglyceride Lipase (MGL)
Type:
Hydrolase
Mol. Mass.:
33391.67
Organism:
Mus musculus (mouse)
Description:
Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells.
Residue:
303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRIDSSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP
  
Inhibitor
Name:
BDBM50461660
Synonyms:
CHEMBL4228101
Type:
Small organic molecule
Emp. Form.:
C21H22F3NO2
Mol. Mass.:
377.4001
SMILES:
FC(F)(F)c1ccc(cc1)-c1cccc(NC(=O)OCC2CCCCC2)c1
Structure:
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