Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50035097
Substrate
n/a
Meas. Tech.
ChEMBL_1772773 (CHEMBL4229765)
Ki
44±n/a nM
Citation
 Ramesh, R; Reddy, DS Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds. J Med Chem 61:3779-3798 (2018) [PubMed]  Article 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
  
Inhibitor
Name:
BDBM50035097
Synonyms:
1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-piperidine](L-687,384) | 1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-piperidine]; HCl | 1''-benzylspiro[1,2,3,4-tetrahydronaphthalene-1,4''-(hexahydropyridine)] | 1'-benzylspiro[1,2,3,4-tetrahydronaphthalene-1,4'-(hexahydropyridine)](L-687,384) | CHEMBL1256916 | CHEMBL303336 | L-687384
Type:
Small organic molecule
Emp. Form.:
C21H25N
Mol. Mass.:
291.4299
SMILES:
C(N1CCC2(CCCc3ccccc23)CC1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: