Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50462120
Substrate
n/a
Meas. Tech.
ChEMBL_1772773 (CHEMBL4229765)
Ki
460±n/a nM
Citation
 Ramesh, R; Reddy, DS Quest for Novel Chemical Entities through Incorporation of Silicon in Drug Scaffolds. J Med Chem 61:3779-3798 (2018) [PubMed]  Article 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
  
Inhibitor
Name:
BDBM50462120
Synonyms:
CHEMBL4243361
Type:
Small organic molecule
Emp. Form.:
C21H27NOSi
Mol. Mass.:
337.5307
SMILES:
[#6]-[#8]-c1ccc(-[#6]-[#7]-2-[#6]-[#6][Si;v4]3([#6]-[#6]-[#6]-c4ccccc34)[#6]-[#6]-2)cc1
Structure:
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