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Target
Histone deacetylase 3
Ligand
BDBM50463684
Substrate
n/a
Meas. Tech.
ChEMBL_1779021 (CHEMBL4236013)
IC50
100±n/a nM
Citation
 Zhu, Q; Yu, X; Shen, Q; Zhang, Q; Su, M; Zhou, Y; Li, J; Chen, Y; Lu, W A series of camptothecin prodrugs exhibit HDAC inhibition activity. Bioorg Med Chem 26:4706-4715 (2018) [PubMed]  Article 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM50463684
Synonyms:
CHEMBL4241658
Type:
Small organic molecule
Emp. Form.:
C30H33N3O8
Mol. Mass.:
563.5983
SMILES:
CCc1c2Cn3c(cc4c(COC(=O)[C@@]4(CC)OC(=O)CCCCCCC(=O)NO)c3=O)-c2nc2ccc(O)cc12 |r|
Structure:
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