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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50464043
Substrate
n/a
Meas. Tech.
ChEMBL_1779840 (CHEMBL4236832)
EC50
3690±n/a nM
Citation
 Laghezza, A; Piemontese, L; Cerchia, C; Montanari, R; Capelli, D; Giudici, M; Crestani, M; Tortorella, P; Peiretti, F; Pochetti, G; Lavecchia, A; Loiodice, F Identification of the First PPAR?/? Dual Agonist Able To Bind to Canonical and Alternative Sites of PPAR? and To Inhibit Its Cdk5-Mediated Phosphorylation. J Med Chem 61:8282-8298 (2018) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50464043
Synonyms:
CHEMBL4237252
Type:
Small organic molecule
Emp. Form.:
C27H22O3
Mol. Mass.:
394.4618
SMILES:
OC(=O)[C@H](Cc1ccc(cc1)-c1ccccc1)Oc1ccc(cc1)-c1ccccc1 |r|
Structure:
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