Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor
Ligand
BDBM50467129
Substrate
n/a
Meas. Tech.
ChEMBL_1795011 (CHEMBL4267128)
IC50
0.700000±n/a nM
Citation
 Choung, W; Jung, HJ; Nam, EH; Yang, D; Yoo, B; Choi, H; Lee, BR; Park, M; Jang, SM; Lim, JS; Kim, KH; Chin, J; Jung, K; Lee, G; Kim, SH Discovery of the bifunctional modulator of angiotensin II type 1 receptor (AT1R) and PPAR? derived from the AT1R antagonist, Fimasartan. Bioorg Med Chem Lett 28:3155-3160 (2018) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM50467129
Synonyms:
CHEMBL4278280
Type:
Small organic molecule
Emp. Form.:
C30H33N5O3S
Mol. Mass.:
543.68
SMILES:
CCCCc1nc(C)c(CC(=S)N2CCCC2)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1noc(=O)[nH]1
Structure:
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