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Target
Cyclin-dependent kinase 1
Ligand
BDBM50468265
Substrate
n/a
Meas. Tech.
ChEMBL_1799036 (CHEMBL4271328)
IC50
7.0±n/a nM
Citation
 Kalra, S; Joshi, G; Munshi, A; Kumar, R Structural insights of cyclin dependent kinases: Implications in design of selective inhibitors. Eur J Med Chem 142:424-458 (2017) [PubMed]  Article 
Target
Name:
Cyclin-dependent kinase 1
Synonyms:
CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase
Type:
Enzyme Subunit
Mol. Mass.:
34101.08
Organism:
Homo sapiens (Human)
Description:
P06493
Residue:
297
Sequence:
MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
  
Inhibitor
Name:
BDBM50468265
Synonyms:
CHEMBL4282338
Type:
Small organic molecule
Emp. Form.:
C18H21F3N4O3S
Mol. Mass.:
430.445
SMILES:
C[C@@H](O)[C@@H](C)Oc1nc(Nc2ccc(cc2)[S@](=N)(=O)C2CC2)ncc1C(F)(F)F |r|
Structure:
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