Reaction Details Report a problem with these data
Target
Alpha-1B adrenergic receptor
Ligand
BDBM50474630
Substrate
n/a
Meas. Tech.
ChEMBL_34318 (CHEMBL648102)
Ki
2512±n/a nM
Citation
 Altenbach, RJ; Khilevich, A; Kolasa, T; Rohde, JJ; Bhatia, PA; Patel, MV; Searle, XB; Yang, F; Bunnelle, WH; Tietje, K; Bayburt, EK; Carroll, WA; Meyer, MD; Henry, R; Buckner, SA; Kuk, J; Daza, AV; Milicic, IV; Cain, JC; Kang, CH; Ireland, LM; Carr, TL; Miller, TR; Hancock, AA; Nakane, M; Esbenshade, TA; Brune, ME; O'Neill, AB; Gauvin, DM; Katwala, SP; Holladay, MW; Brioni, JD; Sullivan, JP Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. J Med Chem 47:3220-35 (2004) [PubMed]  Article 
Target
Name:
Alpha-1B adrenergic receptor
Synonyms:
ADA1B_MESAU | ADRA1B | adrenergic Alpha1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
56514.13
Organism:
HAMSTER
Description:
adrenergic Alpha1 0 HAMSTER::P18841
Residue:
515
Sequence:
MNPDLDTGHNTSAPAQWGELKDANFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAIVGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDIWAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGPLLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAGVMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVVGMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFMRILGCQCRSGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGSQRTLPSASPSPGYLGRGAQPPLELCAYPEWKSGALLSLPEPPGRRGRLDSGPLFTFKLLGEPESPGTEGDASNGGCDATTDLANGQPGFKSNMPLAPGHF
  
Inhibitor
Name:
BDBM50474630
Synonyms:
CHEMBL108804
Type:
Small organic molecule
Emp. Form.:
C14H17N3O3S
Mol. Mass.:
307.368
SMILES:
CS(=O)(=O)Nc1c(O)ccc2C(CCCc12)c1c[nH]cn1
Structure:
Search PDB for entries with ligand similarity: