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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM8574
Substrate
n/a
Meas. Tech.
ChEMBL_1969948 (CHEMBL4602766)
IC50
5.0±n/a nM
Citation
 Xu, M; Wang, SL; Zhu, L; Wu, PY; Dai, WB; Rakesh, KP Structure-activity relationship (SAR) studies of synthetic glycogen synthase kinase-3? inhibitors: A critical review. Eur J Med Chem 164:448-470 (2019) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM8574
Synonyms:
4-Acylamino-6-arylfuro[2,3-d]pyrimidine 19 | N-[6-(pyridin-3-yl)furo[2,3-d]pyrimidin-4-yl]cyclopropanecarboxamide
Type:
Small organic molecule
Emp. Form.:
C15H12N4O2
Mol. Mass.:
280.2814
SMILES:
O=C(Nc1ncnc2oc(cc12)-c1cccnc1)C1CC1
Structure:
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