Reaction Details
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Aldo-keto reductase family 1 member B1
Ligand
BDBM50487944
Substrate
n/a
Meas. Tech.
ChEMBL_912706 (CHEMBL3055410)
IC50
34674±n/a nM
Citation
TBA Med Chem Res 21:1665-1676 (2012) Article More Info.:
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
Inhibitor
Name:
BDBM50487944
Synonyms:
CHEMBL2261561
Type:
Small organic molecule
Emp. Form.:
C22H24O6
Mol. Mass.:
384.4224
SMILES:
CCOc1ccc(cc1OC)C(=O)C(\C)=C(\C)C(=O)c1ccc(O)c(OC)c1
Structure:
