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Target
Ecdysone receptor/Gene regulation protein
Ligand
BDBM50178988
Substrate
n/a
Meas. Tech.
ChEMBL_927366 (CHEMBL3072566)
Ki
3.2±n/a nM
Citation
 Tohidi-Esfahani, D; Lawrence, MC; Graham, LD; Hannan, GN; Simpson, AM; Hill, RJ Isoforms of the heteropteran Nezara viridula ecdysone receptor: protein characterisation, RH5992 insecticide binding and homology modelling. Pest Manag Sci 67:1457-67 (2011) [PubMed]  Article 
Target
Name:
Ecdysone receptor/Gene regulation protein
Synonyms:
Ecdysone receptor
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 927366
Components:
This complex has 2 components.
Component 1
Name:
Ecdysone receptor
Synonyms:
20-hydroxy-ecdysone receptor | 20E receptor | ECR_HELVI | EcR | EcRH | Ecdysone receptor | Ecdysteroid receptor | HvEcR | NR1H1 | Nuclear receptor subfamily 1 group H member 1
Type:
PROTEIN
Mol. Mass.:
64635.62
Organism:
Heliothis virescens
Description:
ChEMBL_106726
Residue:
576
Sequence:
MSLGARGYRRCDTLADMRRRWYNNGPFQTLRMLEESSSEVTSSSALGLPPAMVMSPESLASPEIGGLELWGYDDGITYSMAQSLGTCTMEQQQPQPQQQPQQTQPLPSMPLPMPPTTPKSENESMSSGREELSPASSVNGCSTDGEARRQKKGPAPRQQEELCLVCGDRASGYHYNALTCEGCKGFFRRSVTKNAVYICKFGHACEMDIYMRRKCQECRLKKCLAVGMRPECVVPENQCAMKRKEKKAQREKDKLPVSTTTVDDHMPPIMQCDPPPPEAARILECVQHEVVPRFLNEKLMEQNRLKNVPPLTANQKSLIARLVWYQEGYEQPSEEDLKRVTQSDEDDEDSDMPFRQITEMTILTVQLIVEFAKGLPGFAKISQSDQITLLKACSSEVMMLRVARRYDAATDSVLFANNQAYTRDNYRKAGMAYVIEDLLHFCRCMYSMMMDNVHYALLTAIVIFSDRPGLEQPLLVEEIQRYYLNTLRVYILNQNSASPRGAVIFGEILGILTEIRTLGMQNSNMCISLKLKNRKLPPFLEEIWDVADVATTATPVAAEAPAPLAPAPPARPPATV
  
Component 2
Name:
Gene regulation protein
Synonyms:
Gene regulation protein
Type:
PROTEIN
Mol. Mass.:
29925.89
Organism:
Heliothis virescens
Description:
ChEMBL_106726
Residue:
264
Sequence:
AAVQELSIERLLEMESLVADPSEEFQFLRVGPDSNVPPKFRAPVSSLCQIGNKQIAALVVWARDIPHFSQLEMEDQILLIKGSWNELLLFAIAWRSMEFLTEERDGVDGTGNRTTSPPQLMCLMPGMTLHRNSALQAGVGQIFDRVLSELSLKMRTLRVDQAEYVALKAIILLNPDVKGLKNRQEVEVLREKMFLCLDEYCRRSRSSEEGRFAALLLRLPALRSISLKSFEHLFFFHLVADTSIAGYIRDALRNHAPPIDTNMM
  
Inhibitor
Name:
BDBM50178988
Synonyms:
CHEBI:38452 | Tebufenozide
Type:
Small organic molecule
Emp. Form.:
C22H28N2O2
Mol. Mass.:
352.4699
SMILES:
CCc1ccc(cc1)C(=O)NN(C(=O)c1cc(C)cc(C)c1)C(C)(C)C
Structure:
Search PDB for entries with ligand similarity: