Target
Procathepsin L
Ligand
BDBM50491155
Substrate
n/a
Meas. Tech.
ChEMBL_957451 (CHEMBL2378147)
IC50
338±n/a nM
Citation
 Song, JJones, LMChavarria, GECharlton-Sevcik, AKJantz, AJohansen, ABayeh, LSoeung, VSnyder, LKLade, SDChaplin, DJTrawick, MLPinney, KG Small-molecule inhibitors of cathepsin L incorporating functionalized ring-fused molecular frameworks. Bioorg Med Chem Lett 23:2801-7 (2013) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50491155
Synonyms:
CHEMBL2376004
Type:
Small organic molecule
Emp. Form.:
C10H10N6O4S
Mol. Mass.:
310.289
SMILES:
NC(=S)N\N=C1/CCNc2c1cc(cc2[N+]([O-])=O)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: