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Target
Kappa-type opioid receptor
Ligand
BDBM50453377
Substrate
n/a
Meas. Tech.
ChEMBL_146793 (CHEMBL754153)
Ki
23±n/a nM
Citation
 Zimmerman, DM; Gidda, JS; Cantrell, BE; Schoepp, DD; Johnson, BG; Leander, JD Discovery of a potent, peripherally selective trans-3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonist for the treatment of gastrointestinal motility disorders. J Med Chem 37:2262-5 (1994) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50453377
Synonyms:
CHEMBL2115154
Type:
Small organic molecule
Emp. Form.:
C29H40N2O4
Mol. Mass.:
480.6389
SMILES:
CC(C)COC(=O)CNC(=O)[C@H](CN1CC[C@](C)([C@@H](C)C1)c1cccc(O)c1)Cc1ccccc1
Structure:
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