Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50495533
Substrate
n/a
Meas. Tech.
ChEMBL_1290434 (CHEMBL3119343)
Ki
21±n/a nM
Citation
 Zampieri, D; Laurini, E; Vio, L; Golob, S; Fermeglia, M; Pricl, S; Mamolo, MG Synthesis and receptor binding studies of some new arylcarboxamide derivatives as sigma-1 ligands. Bioorg Med Chem Lett 24:1021-5 (2014) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50495533
Synonyms:
CHEMBL3116462
Type:
Small organic molecule
Emp. Form.:
C20H27ClN2O2
Mol. Mass.:
362.894
SMILES:
Cl.CCN(CC1CCN(Cc2ccccc2)CC1)C(=O)c1ccco1
Structure:
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