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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50496072
Substrate
n/a
Meas. Tech.
ChEMBL_1293611 (CHEMBL3123036)
IC50
4200±n/a nM
Citation
 Seerden, JP; Leusink-Ionescu, G; Leguijt, R; Saccavini, C; Gelens, E; Dros, B; Woudenberg-Vrenken, T; Molema, G; Kamps, JA; Kellogg, RM Syntheses and structure-activity relationships for some triazolyl p38? MAPK inhibitors. Bioorg Med Chem Lett 24:1352-7 (2014) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50496072
Synonyms:
CHEMBL3120992
Type:
Small organic molecule
Emp. Form.:
C24H28FN7O3
Mol. Mass.:
481.5226
SMILES:
C[N+](C)(C)CCO.Cn1c(nc(c1-c1ccncc1)-c1ccc(F)cc1)-c1cnnn1CC([O-])=O
Structure:
Search PDB for entries with ligand similarity: