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Target
Adenylate cyclase type 1
Ligand
BDBM50497055
Substrate
n/a
Meas. Tech.
ChEMBL_1341454 (CHEMBL3253174)
IC50
4.5±n/a nM
Citation
 Ellefson, CR; Woo, CM; Miller, A; Kehr, JR Synthesis and biological evaluation of some 2-amino-4-aryl-3H-1,5-benzodiazepine analogues of clozapine. J Med Chem 21:952-7 (1978) [PubMed]  Article 
Target
Name:
Adenylate cyclase type 1
Synonyms:
4.6.1.1 | Adcy1 | Adenylate cyclase | Synonyms=Adcy1_predicted
Type:
PROTEIN
Mol. Mass.:
108287.66
Organism:
Rattus norvegicus
Description:
ChEMBL_104763
Residue:
967
Sequence:
MGSAVAEQGVWQLLLVTFVSYALLPVRSLLAIGFGLVVAASHLLVTAALVPAKRPRLWRTLGANALLFFGVNMYGVFVRILTERSQRKAFLQARNCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGLTQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGHGHERNTFLRTHNIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFTSAVVLALILATLFGLIYLLVIPQSVAVLLLLVFSICFLVACTLYLHITRVQCFPGCLTIQIRTALCVFIVVLIYSVAQGCVVSCLPWAWSSHSNSSLVVLAAGGRRTVLPALPCESAHHGLLCCLVGTLPLAIFLRVSSLPKMILLSGLTTSYILVLELSGYTKVGGGALSGRSYEPIMAILLFSCTLALHARQVDVRLRLDYLWAAQAEEERDDMERVKLDNKRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEIIADFDELMDKDFYKDLEKIKTIGSTYMAAVGLAPTAGTRAKKSISSHLSTLADFAIDMFDVLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQVTEEVHRLLNRCSYQFVCRGKVSVKGKGEMLTYFLEGRTDGSSSHSRSLRLERRMFPYGRGGGGQARRPPLCPAAGPPIKPGLSPAPTSQYLSSTAAGKEA
  
Inhibitor
Name:
BDBM50497055
Synonyms:
CHEMBL3244459
Type:
Small organic molecule
Emp. Form.:
C26H25N3
Mol. Mass.:
379.4968
SMILES:
C1CN(CCC1c1ccccc1)C1=Nc2ccccc2N=C(C1)c1ccccc1 |c:23,t:14|
Structure:
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