Reaction Details Report a problem with these data
Target
Platelet-activating factor receptor
Ligand
BDBM50045993
Substrate
n/a
Meas. Tech.
ChEMBL_151692 (CHEMBL760442)
IC50
14±n/a nM
Citation
Carceller, E; Merlos, M; Giral, M; Almansa, C; Bartrolí, J; García-Rafanell, J; Forn, J Synthesis and structure-activity relationships of 1-acyl-4-((2-methyl-3-pyridyl)cyanomethyl)piperazines as PAF antagonists. J Med Chem 36:2984-97 (1993) [PubMed] Article
More Info.:
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Guinea pig
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
Inhibitor
Name:
BDBM50045993
Synonyms:
(3-{4-[Cyano-(2-methyl-pyridin-3-yl)-methyl]-piperazin-1-yl}-3-oxo-1-phenyl-propyl)-carbamic acid ethyl ester | CHEMBL318563
Type:
Small organic molecule
Emp. Form.:
C24H29N5O3
Mol. Mass.:
435.5188
SMILES:
CCOC(=O)NC(CC(=O)N1CCN(CC1)C(C#N)c1cccnc1C)c1ccccc1