Reaction Details Report a problem with these data
Target
Protein translocase subunit SecA 2
Ligand
BDBM50498946
Substrate
n/a
Meas. Tech.
ChEMBL_1540161 (CHEMBL3738516)
IC50
15000±n/a nM
Citation
 Jin, J; Cui, J; Chaudhary, AS; Hsieh, YH; Damera, K; Zhang, H; Yang, H; Wang, B; Tai, PC Evaluation of small molecule SecA inhibitors against methicillin-resistant Staphylococcus aureus. Bioorg Med Chem 23:7061-8 (2015) [PubMed]  Article 
Target
Name:
Protein translocase subunit SecA 2
Synonyms:
Protein translocase subunit SecA 2 | SECA2_STAA8 | secA2
Type:
PROTEIN
Mol. Mass.:
90917.88
Organism:
Staphylococcus aureus (strain NCTC 8325)
Description:
ChEMBL_116911
Residue:
796
Sequence:
MKHKLDVTINELRLKSIRKIVKRINTWSDEVKSYSDDALKQKTIEFKERLASGVDTLDTLLPEAYAVAREASWRVLGMYPKEVQLIGAIVLHEGNIAEMQTGEGKTLTATMPLYLNALSGKGTYLITTNDYLAKRDFEEMQPLYEWLGLTASLGFVDIVDYEYQKGEKRNIYEHDIIYTTNGRLGFDYLIDNLADSAEGKFLPQLNYGIIDEVDSIILDAAQTPLVISGAPRLQSNLFHIVKEFVDTLIEDVHFKMKKTKKEIWLLNQGIEAAQSYFNVEDLYSEQAMVLVRNINLALRAQYLFESNVDYFVYNGDIVLIDRITGRMLPGTKLQAGLHQAIEAKEGMEVSTDKSVMATITFQNLFKLFESFSGMTATGKLGESEFFDLYSKIVVQVPTDKAIQRIDEPDKVFRSVDEKNIAMIHDIVELHETGRPVLLITRTAEAAEYFSKVLFQMDIPNNLLIAQNVAKEAQMIAEAGQIGSMTVATSMAGRGTDIKLGEGVEALGGLAVIIHEHMENSRVDRQLRGRSGRQGDPGSSCIYISLDDYLVKRWSDSNLAENNQLYSLDAQRLSQSNLFNRKVKQIVVKAQRISEEQGVKAREMANEFEKSISIQRDLVYEERNRVLEIDDAENQDFKALAKDVFEMFVNEEKVLTKSRVVEYIYQNLSFQFNKDVACVNFKDKQAVVTFLLEQFEKQLALNRKNMQSAYYYNIFVQKVFLKAIDSCWLEQVDYLQQLKASVNQRQNGQRNAIFEYHRVALDSFEVMTRNIKKRMVKNICQSMITFDKEGMPVIHFP
  
Inhibitor
Name:
BDBM50498946
Synonyms:
CHEMBL3735815
Type:
Small organic molecule
Emp. Form.:
C19H22O3
Mol. Mass.:
298.3762
SMILES:
CCCCCCC1c2ccc(O)cc2Oc2cc(O)ccc12
Structure:
Search PDB for entries with ligand similarity: