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Target
Squalene synthase
Ligand
BDBM50049217
Substrate
n/a
Meas. Tech.
ChEMBL_202112 (CHEMBL808970)
IC50
13±n/a nM
Citation
 Magnin, DR; Biller, SA; Chen, Y; Dickson, JK; Fryszman, OM; Lawrence, RM; Logan, JV; Sieber-McMaster, ES; Sulsky, RB; Traeger, SC; Hsieh, DC; Lan, SJ; Rinehart, JK; Harrity, TW; Jolibois, KG; Kunselman, LK; Rich, LC; Slusarchyk, DA; Ciosek, CP alpha-Phosphonosulfonic acids: potent and selective inhibitors of squalene synthase. J Med Chem 39:657-60 (1996) [PubMed]  Article 
Target
Name:
Squalene synthase
Synonyms:
FDFT_RAT | FPP:FPP farnesyltransferase | Farnesyl-diphosphate farnesyltransferase | Fdft1 | SQS | SS | Squalene synthetase
Type:
PROTEIN
Mol. Mass.:
48109.41
Organism:
Rattus norvegicus
Description:
ChEMBL_1336736
Residue:
416
Sequence:
MEFVKCLGHPEEFYNLLRFRMGGRRNFIPKMDRNSLSNSLKTCYKYLDQTSRSFAAVIQALDGDIRHAVCVFYLILRAMDTVEDDMAISVEKKIPLLRNFHTFLYEPEWRFTESKEKHRVVLEDFPTISLEFRNLAEKYQTVIADICHRMGCGMAEFLNKDVTSKQDWDKYCHYVAGLVGIGLSRLFSASEFEDPIVGEDTECANSMGLFLQKTNIIRDYLEDQQEGRQFWPQEVWGKYVKKLEDFVKPENVDVAVKCLNELITNALQHIPDVITYLSRLRNQSVFNFCAIPQVMAIATLAACYNNHQVFKGVVKIRKGQAVTLMMDATNMPAVKAIIYQYIEEIYHRVPNSDPSASKAKQLISNIRTQSLPNCQLISRSHYSPIYLSFIMLLAALSWQYLSTLSQVTEDYVQREH
  
Inhibitor
Name:
BDBM50049217
Synonyms:
CHEMBL158517 | Tripotassium salt of 1-Phosphono-4-(4'-pyridin-2-yl-biphenyl-4-yl)-butane-1-sulfonic acid
Type:
Small organic molecule
Emp. Form.:
C21H19NO6PS
Mol. Mass.:
444.419
SMILES:
[O-]P([O-])(=O)C(CCCc1ccc(cc1)-c1ccc(cc1)-c1ccccn1)S([O-])(=O)=O
Structure:
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