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Target
Sterol O-acyltransferase 1
Ligand
BDBM50034742
Substrate
n/a
Meas. Tech.
ChEMBL_28795 (CHEMBL641705)
IC50
2400±n/a nM
Citation
 Vaccaro, W; Amore, C; Berger, J; Burrier, R; Clader, J; Davis, H; Domalski, M; Fevig, T; Salisbury, B; Sher, R Inhibitors of acyl CoA:cholesterol acyltransferase. J Med Chem 39:1704-19 (1996) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rat
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50034742
Synonyms:
CHEMBL289997 | N-[2-(4-Methoxy-phenyl)-1-(3-methoxy-phenyl)-ethyl]-2,2-diphenyl-acetamide
Type:
Small organic molecule
Emp. Form.:
C30H29NO3
Mol. Mass.:
451.5562
SMILES:
COc1ccc(CC(NC(=O)C(c2ccccc2)c2ccccc2)c2cccc(OC)c2)cc1
Structure:
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