Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM50051355
Substrate
n/a
Meas. Tech.
ChEMBL_31838 (CHEMBL641515)
Ki
28000±n/a nM
Citation
 Karton, Y; Jiang, JL; Ji, XD; Melman, N; Olah, ME; Stiles, GL; Jacobson, KA Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists. J Med Chem 39:2293-301 (1996) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36197.32
Organism:
Human
Description:
P0DMS8
Residue:
318
Sequence:
MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIAVGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKRVTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYFSFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFALSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKACVVCHPSDSLDTSIEKNSE
  
Inhibitor
Name:
BDBM50051355
Synonyms:
2-{4-[(2-Amino-4-oxo-1,4-dihydro-pteridin-6-ylamino)-methyl]-benzoylamino}-pentanedioic acid | CHEMBL74430
Type:
Small organic molecule
Emp. Form.:
C19H19N7O6
Mol. Mass.:
441.3975
SMILES:
Nc1nc2ncc(NCc3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O)nc2c(=O)[nH]1
Structure:
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