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Target
Carbonic anhydrase 2
Ligand
BDBM50504623
Substrate
n/a
Meas. Tech.
ChEMBL_1815682 (CHEMBL4315256)
Ki
28±n/a nM
Citation
 Abo-Ashour, MF; Eldehna, WM; Nocentini, A; Bonardi, A; Bua, S; Ibrahim, HS; Elaasser, MM; Kry?tof, V; Jorda, R; Gratteri, P; Abou-Seri, SM; Supuran, CT 3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights. Eur J Med Chem 184:0 (2019) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50504623
Synonyms:
CHEMBL4517834
Type:
Small organic molecule
Emp. Form.:
C15H13ClN4O3S
Mol. Mass.:
364.807
SMILES:
CN1C(=O)\C(=N/Nc2ccc(cc2)S(N)(=O)=O)c2cc(Cl)ccc12
Structure:
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