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Target
Urotensin-2 receptor
Ligand
BDBM50508368
Substrate
n/a
Meas. Tech.
ChEMBL_1832932 (CHEMBL4332940)
IC50
68±n/a nM
Citation
 Lim, CJ; Kim, NH; Park, HJ; Lee, BH; Oh, KS; Yi, KY Synthesis and SAR of 5-aryl-furan-2-carboxamide derivatives as potent urotensin-II receptor antagonists. Bioorg Med Chem Lett 29:577-580 (2019) [PubMed]  Article 
Target
Name:
Urotensin-2 receptor
Synonyms:
G-protein coupled receptor 14 | GPR14 | UR-II-R | UR2R_HUMAN | UTS2R | Urotensin II receptor | Urotensin-II
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42159.71
Organism:
Homo sapiens (Human)
Description:
Urotensin-II UTS2R HUMAN::Q9UKP6
Residue:
389
Sequence:
MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSAMGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGDVGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLLTLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRRSQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLTTCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLSSCSPQPTDSLVLAPAAPARPAPEGPRAPA
  
Inhibitor
Name:
BDBM50508368
Synonyms:
CHEMBL4538387
Type:
Small organic molecule
Emp. Form.:
C27H29ClFN3O3
Mol. Mass.:
497.989
SMILES:
Fc1ccc(cc1)-c1ccc(o1)C(=O)N1CCN(Cc2ccc(OC3CCNCC3)c(Cl)c2)CC1
Structure:
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