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Target
Prolyl 3-hydroxylase OGFOD1
Ligand
BDBM118338
Substrate
n/a
Meas. Tech.
ChEMBL_1840412 (CHEMBL4340711)
IC50
5100±n/a nM
Citation
 Langley, GW; Abboud, MI; Lohans, CT; Schofield, CJ Inhibition of a viral prolyl hydroxylase. Bioorg Med Chem 27:2405-2412 (2019) [PubMed]  Article 
Target
Name:
Prolyl 3-hydroxylase OGFOD1
Synonyms:
1.14.11.- | 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 1 | KIAA1612 | OGFD1_HUMAN | OGFOD1 | Prolyl 3-hydroxylase OGFOD1 | TPA1 | Termination and polyadenylation 1 homolog | uS12 prolyl 3-hydroxylase
Type:
PROTEIN
Mol. Mass.:
63220.24
Organism:
Human
Description:
ChEMBL_119148
Residue:
542
Sequence:
MNGKRPAEPGPARVGKKGKKEVMAEFSDAVTEETLKKQVAEAWSRRTPFSHEVIVMDMDPFLHCVIPNFIQSQDFLEGLQKELMNLDFHEKYNDLYKFQQSDDLKKRREPHISTLRKILFEDFRSWLSDISKIDLESTIDMSCAKYEFTDALLCHDDELEGRRIAFILYLVPPWDRSMGGTLDLYSIDEHFQPKQIVKSLIPSWNKLVFFEVSPVSFHQVSEVLSEEKSRLSISGWFHGPSLTRPPNYFEPPIPRSPHIPQDHEILYDWINPTYLDMDYQVQIQEEFEESSEILLKEFLKPEKFTKVCEALEHGHVEWSSRGPPNKRFYEKAEESKLPEILKECMKLFRSEALFLLLSNFTGLKLHFLAPSEEDEMNDKKEAETTDITEEGTSHSPPEPENNQMAISNNSQQSNEQTDPEPEENETKKESSVPMCQGELRHWKTGHYTLIHDHSKAEFALDLILYCGCEGWEPEYGGFTSYIAKGEDEELLTVNPESNSLALVYRDRETLKFVKHINHRSLEQKKTFPNRTGFWDFSFIYYE
  
Inhibitor
Name:
BDBM118338
Synonyms:
US8653111, 62
Type:
Small organic molecule
Emp. Form.:
C15H16N6O3
Mol. Mass.:
328.3259
SMILES:
CC(C)(C)OC(=O)c1ccc(nc1)-n1[nH]cc(-n2ccnn2)c1=O
Structure:
Search PDB for entries with ligand similarity: