Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM50064521
Substrate
n/a
Meas. Tech.
ChEMBL_145428 (CHEMBL748773)
Ki
0.039000±n/a nM
Citation
Thomas, JB; Mascarella, SW; Rothman, RB; Partilla, JS; Xu, H; McCullough, KB; Dersch, CM; Cantrell, BE; Zimmerman, DM; Carroll, FI Investigation of the N-substituent conformation governing potency and mu receptor subtype-selectivity in (+)-(3R, 4R)-dimethyl-4-(3-hydroxyphenyl)piperidine opioid antagonists. J Med Chem 41:1980-90 (1998) [PubMed] Article
More Info.:
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOR-1 | Mu opioid receptor | Mu-type opioid receptor (Mu) | OPIATE Mu | OPRM1 | OPRM_CAVPO
Type:
Enzyme Catalytic Domain
Mol. Mass.:
11165.58
Organism:
GUINEA PIG
Description:
P97266
Residue:
98
Sequence:
YTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKTVNVCNWI
Inhibitor
Name:
BDBM50064521
Synonyms:
3-[(3R,4R)-3,4-Dimethyl-1-((E)-3-phenyl-allyl)-piperidin-4-yl]-phenol | 3-[3,4-Dimethyl-1-(3-phenyl-allyl)-piperidin-4-yl]-phenol | CHEMBL51838
Type:
Small organic molecule
Emp. Form.:
C22H27NO
Mol. Mass.:
321.4559
SMILES:
C[C@H]1CN(C\C=C\c2ccccc2)CC[C@@]1(C)c1cccc(O)c1