Reaction Details Report a problem with these data
Target
Apoptosis regulator Bcl-2
Ligand
BDBM50511135
Substrate
n/a
Meas. Tech.
ChEMBL_1843890 (CHEMBL4344317)
Ki
5600±n/a nM
Citation
 Kump, KJ; Miao, L; Mady, ASA; Ansari, NH; Shrestha, UK; Yang, Y; Pal, M; Liao, C; Perdih, A; Abulwerdi, FA; Chinnaswamy, K; Meagher, JL; Carlson, JM; Khanna, M; Stuckey, JA; Nikolovska-Coleska, Z Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins. J Med Chem 63:2489-2510 (2020) [PubMed]  Article 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM50511135
Synonyms:
CHEMBL4457901
Type:
Small organic molecule
Emp. Form.:
C25H21NO4S2
Mol. Mass.:
463.569
SMILES:
OC(=O)c1cc(SCCc2ccccc2)ccc1NS(=O)(=O)c1ccc2ccccc2c1
Structure:
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