Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM50514545
Substrate
n/a
Meas. Tech.
ChEMBL_1857507 (CHEMBL4358236)
Ki
9.8±n/a nM
Citation
 Kamakolanu, UG; Meyer, ME; Yasuda, D; Polgar, WE; Marti, M; Mercatelli, D; Pisaṇ, CA; Brugnoli, A; Morari, M; Zaveri, NT Discovery and Structure-Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson's Disease Models. J Med Chem 63:2688-2704 (2020) [PubMed]  Article 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM50514545
Synonyms:
CHEMBL4435280
Type:
Small organic molecule
Emp. Form.:
C22H32N2
Mol. Mass.:
324.5029
SMILES:
CC(C)[C@H]1CC[C@H](CC1)N1CCC(CC1)n1ccc2ccccc12 |r,wD:6.9,3.2,(20.66,-19.76,;21.96,-18.93,;23.33,-19.65,;21.9,-17.39,;23.2,-16.56,;23.13,-15.02,;21.77,-14.31,;20.47,-15.14,;20.53,-16.67,;21.69,-12.77,;20.33,-12.06,;20.26,-10.53,;21.56,-9.69,;22.93,-10.4,;23,-11.94,;21.48,-8.16,;22.69,-7.2,;22.14,-5.76,;20.61,-5.84,;19.52,-4.75,;18.04,-5.14,;17.64,-6.63,;18.72,-7.71,;20.19,-7.32,)|
Structure:
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