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Target
Mu-type opioid receptor
Ligand
BDBM50514548
Substrate
n/a
Meas. Tech.
ChEMBL_1857508 (CHEMBL4358237)
Ki
604±n/a nM
Citation
 Kamakolanu, UG; Meyer, ME; Yasuda, D; Polgar, WE; Marti, M; Mercatelli, D; Pisaṇ, CA; Brugnoli, A; Morari, M; Zaveri, NT Discovery and Structure-Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson's Disease Models. J Med Chem 63:2688-2704 (2020) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50514548
Synonyms:
CHEMBL4570328
Type:
Small organic molecule
Emp. Form.:
C22H34N2
Mol. Mass.:
326.5188
SMILES:
CC(C)[C@H]1CC[C@H](CC1)N1CCC(CC1)N1CCc2ccccc12 |r,wD:6.9,3.2,(8.81,-19.41,;10.12,-18.58,;11.48,-19.3,;10.05,-17.04,;11.35,-16.22,;11.29,-14.67,;9.93,-13.96,;8.62,-14.79,;8.69,-16.32,;9.85,-12.42,;8.49,-11.71,;8.42,-10.18,;9.71,-9.35,;11.08,-10.05,;11.15,-11.6,;9.64,-7.81,;10.84,-6.85,;10.3,-5.41,;8.76,-5.49,;7.68,-4.4,;6.19,-4.79,;5.79,-6.28,;6.88,-7.36,;8.35,-6.97,)|
Structure:
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