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Target
Mu-type opioid receptor
Ligand
BDBM50514547
Substrate
n/a
Meas. Tech.
ChEMBL_1857508 (CHEMBL4358237)
Ki
46±n/a nM
Citation
 Kamakolanu, UG; Meyer, ME; Yasuda, D; Polgar, WE; Marti, M; Mercatelli, D; Pisaṇ, CA; Brugnoli, A; Morari, M; Zaveri, NT Discovery and Structure-Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson's Disease Models. J Med Chem 63:2688-2704 (2020) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50514547
Synonyms:
CHEMBL4451073
Type:
Small organic molecule
Emp. Form.:
C25H41Cl2N3
Mol. Mass.:
454.519
SMILES:
Cl.Cl.CC(C)[C@H]1CC[C@H](CC1)N1CCC(CC1)n1cc(CCCN)c2ccccc12 |r,wD:8.9,5.2,(67.26,-34.26,;63.86,-34.67,;69.96,-32.54,;69.15,-31.22,;69.88,-29.86,;67.61,-31.26,;66.8,-29.96,;65.25,-30,;64.52,-31.35,;65.34,-32.67,;66.87,-32.62,;62.99,-31.41,;62.26,-32.77,;60.72,-32.82,;59.9,-31.51,;60.63,-30.15,;62.17,-30.1,;58.37,-31.57,;57.43,-30.35,;55.98,-30.88,;54.7,-30.02,;54.81,-28.49,;53.53,-27.63,;53.64,-26.1,;56.04,-32.42,;54.93,-33.49,;55.3,-34.98,;56.79,-35.39,;57.89,-34.32,;57.51,-32.85,)|
Structure:
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