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Target
Mu-type opioid receptor
Ligand
BDBM50514558
Substrate
n/a
Meas. Tech.
ChEMBL_1857508 (CHEMBL4358237)
Ki
269±n/a nM
Citation
 Kamakolanu, UG; Meyer, ME; Yasuda, D; Polgar, WE; Marti, M; Mercatelli, D; Pisaṇ, CA; Brugnoli, A; Morari, M; Zaveri, NT Discovery and Structure-Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson's Disease Models. J Med Chem 63:2688-2704 (2020) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50514558
Synonyms:
CHEMBL4519453
Type:
Small organic molecule
Emp. Form.:
C27H42N4O
Mol. Mass.:
438.6486
SMILES:
CCNCC(=O)NCc1cn(C2CCN(CC2)[C@@H]2CC[C@@H](CC2)C(C)C)c2ccccc12 |r,wD:17.17,20.24,(39.61,-48.97,;40.88,-49.83,;42.26,-49.15,;43.53,-50.01,;44.91,-49.33,;45.02,-47.8,;46.19,-50.19,;47.56,-49.51,;48.84,-50.37,;50.29,-49.84,;51.23,-51.06,;52.77,-51,;53.59,-52.31,;55.12,-52.26,;55.85,-50.9,;55.04,-49.59,;53.49,-49.64,;57.39,-50.84,;58.11,-49.49,;59.66,-49.45,;60.47,-50.76,;59.74,-52.11,;58.2,-52.16,;62.01,-50.71,;62.82,-52.03,;62.75,-49.36,;50.38,-52.34,;50.75,-53.81,;49.65,-54.89,;48.16,-54.47,;47.79,-52.98,;48.9,-51.91,)|
Structure:
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