Reaction Details Report a problem with these data
Target
Mu-type opioid receptor
Ligand
BDBM50514542
Substrate
n/a
Meas. Tech.
ChEMBL_1857508 (CHEMBL4358237)
Ki
453±n/a nM
Citation
 Kamakolanu, UG; Meyer, ME; Yasuda, D; Polgar, WE; Marti, M; Mercatelli, D; Pisaṇ, CA; Brugnoli, A; Morari, M; Zaveri, NT Discovery and Structure-Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson's Disease Models. J Med Chem 63:2688-2704 (2020) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50514542
Synonyms:
CHEMBL4473383
Type:
Small organic molecule
Emp. Form.:
C23H33N3O
Mol. Mass.:
367.5276
SMILES:
CC(C)[C@H]1CC[C@H](CC1)N1CCC(CC1)n1cc(C(N)=O)c2ccccc12 |r,wD:6.9,3.2,(24.31,-8.5,;23.5,-7.18,;24.23,-5.83,;21.96,-7.23,;21.15,-5.92,;19.6,-5.96,;18.88,-7.32,;19.69,-8.63,;21.22,-8.59,;17.34,-7.38,;16.61,-8.73,;15.08,-8.78,;14.26,-7.48,;14.98,-6.11,;16.53,-6.06,;12.72,-7.53,;11.78,-6.31,;10.33,-6.84,;9.06,-5.98,;7.68,-6.66,;9.16,-4.45,;10.39,-8.38,;9.29,-9.45,;9.66,-10.94,;11.14,-11.36,;12.24,-10.29,;11.87,-8.81,)|
Structure:
Search PDB for entries with ligand similarity: