Reaction Details Report a problem with these data
Target
Nociceptin receptor
Ligand
BDBM50514554
Substrate
n/a
Meas. Tech.
ChEMBL_1857507 (CHEMBL4358236)
Ki
24±n/a nM
Citation
 Kamakolanu, UG; Meyer, ME; Yasuda, D; Polgar, WE; Marti, M; Mercatelli, D; Pisaṇ, CA; Brugnoli, A; Morari, M; Zaveri, NT Discovery and Structure-Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson's Disease Models. J Med Chem 63:2688-2704 (2020) [PubMed]  Article 
Target
Name:
Nociceptin receptor
Synonyms:
KOR-3 | Kappa-type 3 opioid receptor | Mu-type opioid receptor (Mu) | NOP | Nociceptin Receptor (ORL1 Receptor) | Nociceptin receptor (NOP) | Nociceptin receptor (ORL-1) | Nociceptin receptor (ORL1) | Nociceptin/Orphanin FQ, NOP receptor | OOR | OPIATE ORL-1 | OPRL1 | OPRL1 protein | OPRX_HUMAN | ORL1 | ORL1 receptor | Opioid receptor like-1 | Orphanin FQ receptor | Orphanin FQ receptor (ORL1) | P41146
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40702.87
Organism:
Homo sapiens (Human)
Description:
P41146
Residue:
370
Sequence:
MEPLFPAPFWEVIYGSHLQGNLSLLSPNHSLLPPHLLLNASHGAFLPLGLKVTIVGLYLAVCVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTLVLLTLPFQGTDILLGFWPFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVVGVPVAIMGSAQVEDEEIECLVEIPTPQDYWGPVFAICIFLFSFIVPVLVISVCYSLMIRRLRGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGVQPSSETAVAILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTSETVPRPA
  
Inhibitor
Name:
BDBM50514554
Synonyms:
CHEMBL4556227
Type:
Small organic molecule
Emp. Form.:
C26H39N3O
Mol. Mass.:
409.6074
SMILES:
CC(C)[C@H]1CC[C@H](CC1)N1CCC(CC1)n1cc(CN2CC(O)C2)c2ccccc12 |r,wD:6.9,3.2,(51.84,-7.48,;51.03,-6.16,;51.76,-4.81,;49.48,-6.21,;48.68,-4.9,;47.13,-4.94,;46.4,-6.3,;47.22,-7.61,;48.75,-7.57,;44.87,-6.36,;44.14,-7.71,;42.6,-7.76,;41.78,-6.46,;42.51,-5.09,;44.05,-5.04,;40.25,-6.51,;39.3,-5.29,;37.86,-5.82,;36.58,-4.96,;35.2,-5.64,;33.75,-5.14,;33.25,-6.59,;31.87,-7.26,;34.7,-7.09,;37.92,-7.36,;36.81,-8.43,;37.18,-9.92,;38.67,-10.34,;39.77,-9.27,;39.39,-7.79,)|
Structure:
Search PDB for entries with ligand similarity: