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Target
Isocitrate dehydrogenase [NADP] cytoplasmic
Ligand
BDBM377646
Substrate
n/a
Meas. Tech.
ChEMBL_1859386 (CHEMBL4360242)
IC50
6.0±n/a nM
Citation
 Lin, J; Lu, W; Caravella, JA; Campbell, AM; Diebold, RB; Ericsson, A; Fritzen, E; Gustafson, GR; Lancia, DR; Shelekhin, T; Wang, Z; Castro, J; Clarke, A; Gotur, D; Josephine, HR; Katz, M; Diep, H; Kershaw, M; Yao, L; Kauffman, G; Hubbs, SE; Luke, GP; Toms, AV; Wang, L; Bair, KW; Barr, KJ; Dinsmore, C; Walker, D; Ashwell, S Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors. J Med Chem 62:6575-6596 (2019) [PubMed]  Article 
Target
Name:
Isocitrate dehydrogenase [NADP] cytoplasmic
Synonyms:
Cytosolic NADP-isocitrate dehydrogenase | IDH | IDH1 | IDHC_HUMAN | IDP | Isocitrate Dehydrogenase (IDH1) | Isocitrate dehydrogenase 1 (IDH1) | NADP(+)-specific ICDH | Oxalosuccinate decarboxylase | PICD
Type:
Protein
Mol. Mass.:
46661.29
Organism:
Homo sapiens (Human)
Description:
O75874
Residue:
414
Sequence:
MSKKISGGSVVEMQGDEMTRIIWELIKEKLIFPYVELDLHSYDLGIENRDATNDQVTKDAAEAIKKHNVGVKCATITPDEKRVEEFKLKQMWKSPNGTIRNILGGTVFREAIICKNIPRLVSGWVKPIIIGRHAYGDQYRATDFVVPGPGKVEITYTPSDGTQKVTYLVHNFEEGGGVAMGMYNQDKSIEDFAHSSFQMALSKGWPLYLSTKNTILKKYDGRFKDIFQEIYDKQYKSQFEAQKIWYEHRLIDDMVAQAMKSEGGFIWACKNYDGDVQSDSVAQGYGSLGMMTSVLVCPDGKTVEAEAAHGTVTRHYRMYQKGQETSTNPIASIFAWTRGLAHRAKLDNNKELAFFANALEEVSIETIEAGFMTKDLAACIKGLPNVQRSDYLNTFEFMDKLGENLKIKLAQAKL
  
Inhibitor
Name:
BDBM377646
Synonyms:
4-({[6-chloro-2-oxo-7-(pyridin-2-ylmethoxy)-1,2- | US10266495, Compound I-58
Type:
Small organic molecule
Emp. Form.:
C24H19ClN4O3
Mol. Mass.:
446.886
SMILES:
COc1cc(NCc2cc3cc(Cl)c(OCc4ccccn4)cc3[nH]c2=O)ccc1C#N
Structure:
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