Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50515232
Substrate
n/a
Meas. Tech.
ChEMBL_1860515 (CHEMBL4361371)
Ki
0.844000±n/a nM
Citation
 Battiti, FO; Cemaj, SL; Guerrero, AM; Shaik, AB; Lam, J; Rais, R; Slusher, BS; Deschamps, JR; Imler, GH; Newman, AH; Bonifazi, A The Significance of Chirality in Drug Design and Synthesis of Bitopic Ligands as D J Med Chem 62:6287-6314 (2019) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50515232
Synonyms:
CHEMBL4471817
Type:
Small organic molecule
Emp. Form.:
C25H32ClN3O2
Mol. Mass.:
441.993
SMILES:
CCc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl
Structure:
Search PDB for entries with ligand similarity: