Reaction Details Report a problem with these data
Target
C-X-C chemokine receptor type 4
Ligand
BDBM50517798
Substrate
n/a
Meas. Tech.
ChEMBL_1869778 (CHEMBL4370844)
IC50
7.9±n/a nM
Citation
 Sakyiamah, MM; Kobayakawa, T; Fujino, M; Konno, M; Narumi, T; Tanaka, T; Nomura, W; Yamamoto, N; Murakami, T; Tamamura, H Design, synthesis and biological evaluation of low molecular weight CXCR4 ligands. Bioorg Med Chem 27:1130-1138 (2019) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 4
Synonyms:
C-X-C chemokine receptor type 4 | C-X-C chemokine receptor type 4 (CXCR4) | CD_antigen=CD184 | CXC-R4 | CXCR-4 | CXCR4 | CXCR4_HUMAN | FB22 | Fusin | HM89 | LCR1 | LESTR | Leukocyte-derived seven transmembrane domain receptor | NPYRL | SDF-1 receptor | Stromal cell-derived factor 1 receptor
Type:
Enzyme
Mol. Mass.:
39754.61
Organism:
Homo sapiens (Human)
Description:
P61073
Residue:
352
Sequence:
MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVILVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNLYSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEADDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKTTVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPILYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
  
Inhibitor
Name:
BDBM50517798
Synonyms:
CHEMBL4568686
Type:
Small organic molecule
Emp. Form.:
C36H47N7
Mol. Mass.:
577.8053
SMILES:
C(N(Cc1ccccn1)Cc1ccccc1-c1cccc(CN2CCCNCCNCCCNCC2)c1)c1ccccn1
Structure:
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