Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50523349
Substrate
n/a
Meas. Tech.
ChEMBL_1890033 (CHEMBL4391787)
Ki
0.260000±n/a nM
Citation
 Krasavin, M; Shetnev, A; Baykov, S; Kalinin, S; Nocentini, A; Sharoyko, V; Poli, G; Tuccinardi, T; Korsakov, M; Tennikova, TB; Supuran, CT Pyridazinone-substituted benzenesulfonamides display potent inhibition of membrane-bound human carbonic anhydrase IX and promising antiproliferative activity against cancer cell lines. Eur J Med Chem 168:301-314 (2019) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Human
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50523349
Synonyms:
CHEMBL4466844
Type:
Small organic molecule
Emp. Form.:
C16H15N3O3S
Mol. Mass.:
329.374
SMILES:
NS(=O)(=O)c1ccc(cc1)N1N=C(CCC1=O)c1ccccc1 |c:12|
Structure:
Search PDB for entries with ligand similarity: