Reaction Details Report a problem with these data
Target
Xaa-Pro aminopeptidase 2
Ligand
BDBM50078390
Substrate
n/a
Meas. Tech.
ChEMBL_35515 (CHEMBL644748)
IC50
58000±n/a nM
Citation
Maggiora, LL; Orawski, AT; Simmons, WH Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme. J Med Chem 42:2394-402 (1999) [PubMed] Article
More Info.:
Target
Name:
Xaa-Pro aminopeptidase 2
Synonyms:
Membrane-bound aminopeptidase P (APP2) | XPNPEP2 | XPP2_HUMAN | Xaa-Pro aminopeptidase 2
Type:
Enzyme
Mol. Mass.:
75618.88
Organism:
Human
Description:
O43895
Residue:
674
Sequence:
MARAHWGCCPWLVLLCACAWGHTKPVDLGGQDVRNCSTNPPYLPVTVVNTTMSLTALRQQMQTQNLSAYIIPGTDAHMNEYIGQHDERRAWITGFTGSAGTAVVTMKKAAVWTDSRYWTQAERQMDCNWELHKEVGTTPIVTWLLTEIPAGGRVGFDPFLLSIDTWESYDLALQGSNRQLVSITTNLVDLVWGSERPPVPNQPIYALQEAFTGSTWQEKVSGVRSQMQKHQKVPTAVLLSALEETAWLFNLRASDIPYNPFFYSYTLLTDSSIRLFANKSRFSSETLSYLNSSCTGPMCVQIEDYSQVRDSIQAYSLGDVRIWIGTSYTMYGIYEMIPKEKLVTDTYSPVMMTKAVKNSKEQALLKASHVRDAVAVIRYLVWLEKNVPKGTVDEFSGAEIVDKFRGEEQFSSGPSFETISASGLNAALAHYSPTKELNRKLSSDEMYLLDSGGQYWDGTTDITRTVHWGTPSAFQKEAYTRVLIGNIDLSRLIFPAATSGRMVEAFARRALWDAGLNYGHGTGHGIGNFLCVHEWPVGFQSNNIAMAKGMFTSIEPGYYKDGEFGIRLEDVALVVEAKTKYPGSYLTFEVVSFVPYDRNLIDVSLLSPEHLQYLNRYYQTIREKVGPELQRRQLLEEFEWLQQHTEPLAARAPDTASWASVLVVSTLAILGWSV
Inhibitor
Name:
BDBM50078390
Synonyms:
(S)-1-((2S,3S)-3-Amino-2-hydroxy-5-methyl-hexanoyl)-pyrrolidine-2-carboxylic acid ((S)-1-carbamoyl-ethyl)-amide | CHEMBL309274
Type:
Small organic molecule
Emp. Form.:
C15H28N4O4
Mol. Mass.:
328.4072
SMILES:
CC(C)C[C@H](N)[C@H](O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(N)=O