Reaction Details Report a problem with these data
Target
Thiosulfate sulfurtransferase
Ligand
BDBM50203812
Substrate
n/a
Meas. Tech.
ChEMBL_1891102 (CHEMBL4392929)
IC50
>100000±n/a nM
Citation
 Stevens, M; Abdeen, S; Salim, N; Ray, AM; Washburn, A; Chitre, S; Sivinski, J; Park, Y; Hoang, QQ; Chapman, E; Johnson, SM HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. Bioorg Med Chem Lett 29:1106-1112 (2019) [PubMed]  Article 
Target
Name:
Thiosulfate sulfurtransferase
Synonyms:
2.8.1.1 | Rhodanese | THTR_HUMAN | TST | Thiosulfate sulfurtransferase
Type:
PROTEIN
Mol. Mass.:
33432.06
Organism:
Human
Description:
ChEMBL_118080
Residue:
297
Sequence:
MVHQVLYRALVSTKWLAESIRTGKLGPGLRVLDASWYSPGTREARKEYLERHVPGASFFDIEECRDTASPYEMMLPSEAGFAEYVGRLGISNHTHVVVYDGEHLGSFYAPRVWWMFRVFGHRTVSVLNGGFRNWLKEGHPVTSEPSRPEPAVFKATLDRSLLKTYEQVLENLESKRFQLVDSRSQGRFLGTEPEPDAVGLDSGHIRGAVNMPFMDFLTEDGFEKGPEELRALFQTKKVDLSQPLIATCRKGVTACHVALAAYLCGKPDVAVYDGSWSEWFRRAPPESRVSQGKSEKA
  
Inhibitor
Name:
BDBM50203812
Synonyms:
CHEMBL221753 | benzethonium hydrochloride | cid_8478
Type:
Small organic molecule
Emp. Form.:
C27H42NO2
Mol. Mass.:
412.6273
SMILES:
CC(C)(C)CC(C)(C)c1ccc(OCCOCC[N+](C)(C)Cc2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: