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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50523836
Substrate
n/a
Meas. Tech.
ChEMBL_1891209 (CHEMBL4393036)
IC50
>10000±n/a nM
Citation
 Lozinskaya, NA; Babkov, DA; Zaryanova, EV; Bezsonova, EN; Efremov, AM; Tsymlyakov, MD; Anikina, LV; Zakharyascheva, OY; Borisov, AV; Perfilova, VN; Tyurenkov, IN; Proskurnina, MV; Spasov, AA Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3? inhibitors. Bioorg Med Chem 27:1804-1817 (2019) [PubMed]  Article 
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM50523836
Synonyms:
CHEMBL4525020
Type:
Small organic molecule
Emp. Form.:
C17H13BrN2O3
Mol. Mass.:
373.201
SMILES:
COC(=O)Nc1ccc2NC(=O)\C(=C/c3ccc(Br)cc3)c2c1
Structure:
Search PDB for entries with ligand similarity: